{"id":2685,"date":"2025-01-20T17:11:13","date_gmt":"2025-01-20T16:11:13","guid":{"rendered":"https:\/\/www.infectnet.org\/?p=2685"},"modified":"2025-01-20T17:11:13","modified_gmt":"2025-01-20T16:11:13","slug":"beate-kuemmerer-uni-marburg-cap1-geht-viral-in-moskitos","status":"publish","type":"post","link":"https:\/\/infectnet.org\/en\/archive\/2685","title":{"rendered":"Beate K\u00fcmmerer @Uni Marburg: Virenscanner in Moskitos"},"content":{"rendered":"

Vernetzter Start ins neue Jahr<\/strong><\/h2>\n\n\n\n

Von Dr. Nadine Biedenkopf und PD Dr. Beate K\u00fcmmere<\/em>r<\/p>\n\n\n\n

Am 15.01.2025 konnte dank Infect-Net PD Dr. Beate K\u00fcmmerer<\/strong> from the Institut f\u00fcr Virologie der Uniklinik Bonn<\/a> ihre Arbeiten zu Orthoflavivirusinfektionen in Moskitos bei Infect-Net-Mitfrau Dr Nadine Biedenkopf<\/strong><\/a> am Institut f\u00fcr Virologie der Philipps-Universit\u00e4t Marburg<\/a> pr\u00e4sentieren.<\/p>\n\n\n\n

Orthoflaviviren kodieren ein Enzym, das ihnen die Bildung einer Cap1-Struktur am 5\u2018-terminalen Ende des viralen Genoms erlaubt. F\u00fcr Vertebraten ist bekannt, dass diese Cap1-Struktur im Gegensatz zu einer Cap0-Struktur es dem Virus erm\u00f6glicht, sich der Erkennung durch das angeborene Immunsystem zu entziehen und sich somit effizient zu vermehren. Die im Vortrag dargestellten Daten weisen darauf hin, dass auch in Moskitos ein bisher unbekanntes antivirales Protein existiert, das 5\u2018-terminale RNA-Cap-Modifikationen wie Cap0 in Moskitos erkennt. Die Erkennung der Cap0-Struktur konnte sowohl in Moskitozellen als auch in lebenden Moskitos gezeigt werden. Somit ist die Cap1-Struktur am 5′-Ende des viralen Genoms auch in M\u00fccken wichtig f\u00fcr eine effiziente Replikation und letztendlich f\u00fcr die erfolgreiche \u00dcbertragung des Virus durch Moskitos.<\/p>\n\n\n\n

\"Foto:
Die Bonner Virologin PD Dr. Beate K\u00fcmmerer pr\u00e4sentiert ihre Daten zur \u00dcbertragung von Orthoflaviviren in Moskitos an der Philipps-Universit\u00e4t Marburg. Foto: Dr. Thomas Strecker<\/figcaption><\/figure>\n\n\n\n

Ihre spannenden neuen Erkenntnisse zur Cap0-RNA-Erkennung in Moskitos konnten neben Marburger:innen auch externe Mitfrauen online mitverfolgen.
Nach einer intensiven Diskussion der Daten im Anschluss an den Vortrag war au\u00dferdem Zeit f\u00fcr weitere intensive wissenschaftliche Gespr\u00e4che und Austausch mit weiteren Virolog:innen aus Marburg, u.a. auch mit den Infect-Net-Mitfrauen Prof. Andrea Maisner<\/strong><\/a> and Prof. Eva Herker<\/strong><\/a>.<\/p>\n\n\n\n

Titel des Vortrags: Recognition of 2\u2018-O-methyltransferase deficient yellow fever virus in mosquitoes<\/p>\n\n\n\n

\n\n\n\n

English:<\/p>\n\n\n\n

On 15 January 2025, thanks to Infect-Net, PD Dr Beate K\u00fcmmerer<\/strong> from the Institute of Virology at Bonn University Hospital<\/a> was able to present her work on orthoflavivirus infections in mosquitoes to Infect-Net member Dr Nadine Biedenkopf<\/strong><\/a> at the Institute of Virology at Philipps University Marburg<\/a>.<\/em><\/p>\n\n\n\n

Orthoflaviviruses encode an enzyme that allows them to form a Cap1 structure at the 5′-terminal end of the viral genome. For vertebrates, it is known that this Cap1 structure, in contrast to a Cap0 structure, enables the virus to evade recognition by the innate immune system and thus to replicate efficiently. The data presented in the lecture indicate that a previously unknown antiviral protein also exists in mosquitoes that recognises 5′-terminal RNA cap modifications such as Cap0 in mosquitoes. Recognition of the Cap0 structure was demonstrated both in mosquito cells and in living mosquitoes. Thus, the Cap1 structure at the 5′ end of the viral genome is also important in mosquitoes for efficient replication and ultimately for the successful transmission of the virus by mosquitoes.<\/em><\/p>\n\n\n\n

Her exciting new findings on Cap0 RNA recognition in mosquitoes could be followed online not only by Marburg residents but also by external colleagues.
After an intensive discussion of the data following the lecture, there was also time for further intensive scientific discussions and exchange with other virologists from Marburg, including Infect-Net colleagues Prof Andrea Maisner<\/strong> <\/a>and Prof Eva Herker<\/strong><\/a>.<\/em><\/p>\n\n\n\n

Title of the lecture: Recognition of 2′-O-methyltransferase deficient yellow fever virus in mosquitoes<\/em><\/p>\n\n\n\n

<\/p>","protected":false},"excerpt":{"rendered":"

Vernetzter Start ins neue Jahr Von Dr. Nadine Biedenkopf und PD Dr. Beate K\u00fcmmerer Am 15.01.2025 konnte dank Infect-Net PD Dr. Beate K\u00fcmmerer vom Institut f\u00fcr Virologie der Uniklinik Bonn […]<\/p>\n","protected":false},"author":1,"featured_media":2689,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false,"footnotes":""},"categories":[74],"tags":[120,340,341,342,343,344,345,46,61,48],"class_list":["post-2685","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-vortragsreihe","tag-arboviren","tag-beate-kuemmerer","tag-bonn","tag-marburg","tag-nadine-biedenkopf","tag-orthoflaviviren","tag-rna-viren","tag-vernetzung","tag-virologie","tag-vortrag"],"_links":{"self":[{"href":"https:\/\/infectnet.org\/en\/wp-json\/wp\/v2\/posts\/2685","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/infectnet.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/infectnet.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/infectnet.org\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/infectnet.org\/en\/wp-json\/wp\/v2\/comments?post=2685"}],"version-history":[{"count":0,"href":"https:\/\/infectnet.org\/en\/wp-json\/wp\/v2\/posts\/2685\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/infectnet.org\/en\/wp-json\/wp\/v2\/media\/2689"}],"wp:attachment":[{"href":"https:\/\/infectnet.org\/en\/wp-json\/wp\/v2\/media?parent=2685"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/infectnet.org\/en\/wp-json\/wp\/v2\/categories?post=2685"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/infectnet.org\/en\/wp-json\/wp\/v2\/tags?post=2685"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}